Nanoimprint-Engineered Sensing Surface for Enhanced-Sensitivity in Extended-Gate Field-Effect Transistor Biosensors
발표자
이경민 (경기대학교)
연구책임자
하영근 (경기대학교)
초록
내용
Extended-gate field-effect transistor (EGFET) biosensors are promising tools for point-of-care diagnostics (POCD) due to their high sensitivity and label-free detection. However, electrolytes in this system lead to the formation of an electrical double layer (EDL), causing Debye screening that interferes with surface potential changes, significantly reducing sensor sensitivity. In this study, we use nanoimprint lithography (NIL) to modify the sensing surface of the extended gate. Patterns from optical discs were simply transferred onto the sensing surface using a PDMS mold to form concave surface structures. These features help suppress EDL formation in concave regions, thereby mitigating the Debye screening effect. Additionally, the extended-gate design allows the sensing part to be easily replaced, making the sensor reusable. This reusability, combined with straightforward patterning, makes the approach highly suitable for practical point-of-care applications.