Near-Infrared (NIR)-Emissive Bioluminescent Polymersomes for Stimulating Collagen Synthesis and Cell Migration in Wound Healing
발표자
정승오 (건국대학교)
연구책임자
김혜민 (건국대학교)
초록
내용
Photobiomodulation (PBM) is a therapeutic approach that uses light to stimulate cellular activity and regulate biological responses. While conventional PBM relies on external light sources with precise control over intensity and wavelength, these systems are often expensive and limited to surface-level applications. In this study, we present near-infrared (NIR)-emissive bioluminescent polymersomes as a self-contained PBM platform independent of external light sources. Luciferase enzymes and carbon dots (CDs) are co-encapsulated within self-assembled polymersomes, which protect the functional components and facilitate sustained bioluminescence. NIR emission is achieved via bioluminescence resonance energy transfer (BRET) between luciferase and CDs, promoting wound healing by enhancing collagen synthesis and cell migration. This system offers a promising strategy for non-invasive PBM therapy with potential applications in deep tissue regeneration.