Zinc Ion-Releasing Bioactive Polymeric Adhesives for Improved Wound Healing
발표자
정재성 (인천대학교)
연구책임자
박경민 (인천대학교)
초록
내용
Tissue adhesives are gaining worldwide attention for wound management. Traditional wound dressings (e.g., gauze and films) have limitations such as poor adhesion and incomplete hemostasis. To overcome these, bioactive adhesive hydrogels have emerged as promising alternatives. Among various strategies, incorporating zinc ions (Zn2+) is notable for promoting hemostasis, immune modulation, angiogenesis, and tissue remodeling. Herein, we developed bioactive hydrogel adhesives via a zinc peroxide (ZnO2)-mediated disulfide bond and thiol-ene crosslinking. Our hydrogel showed tunable mechanical properties depending on ZnO2 content. Our adhesive hydrogels sustainably release Zn2+ and H2O2 for up to 3 weeks with strong tissue adhesiveness. In vivo, our bioactive adhesives enhanced wound healing, such as hemostasis, immunomodulation, angiogenesis, and tissue remodeling. Overall, our Zn2+-releasing bioactive hydrogel adhesives have considerable potential as advanced wound management adhesives.