Fabrication and Evaluation of an Oxidized Starch-Based Powder-Type Anti-Adhesion Agent with Improved Tissue Adhesiveness
발표자
김병주 (금오공과대학교)
연구책임자
권오형 (금오공과대학교)
초록
내용
Adhesions, often occurring after surgery due to excessive fibrous tissue formation between organs or tissues, can lead to various complications, necessitating effective anti-adhesion strategies. In this study, a powder-type anti-adhesion agent was fabricated using dialdehyde starch (DAS), synthesized via oxidative modification, and polyvinylpyrrolidone (PVP). DAS and PVP were used to improve adhesive properties. DAS was cross-linked using glyoxal. The tissue adhesion property was influenced by the ratio of DAS to PVP, the concentration of cross-linking agent, and the reaction duration. As a result, the x-DAS/PVP (7:3) powder formulation exhibited the highest adhesive performance. From the in vitro test, the powder was biocompatible and degraded within 7 days.In vivo animal studies confirmed effective reduction of tissue adhesion. x-DAS/PVP powder-type anti-adhesion agent is suitable for both laparoscopic and open surgery.