Progression of immunotherapeutic approaches via combined induction of ferroptosis using biodegradable Nano-Sized Metal-Organic Framework
발표자
김영준 (울산과학기술원)
연구책임자
유자형 (UNIST)
초록
내용
In the field of advancing cancer nanomedicine, various treatments encounter challenges attributed to tumor resistance. The resistance of tumor cells to apoptosis and immune responses has instigated an exploration into the immunogenicity of apoptosis, traditionally regarded as low compared to necrosis. Consequently, this study introduces iron oxide with PCN-224, highly crystal inorganic-organic networks between zirconium metal cluster and TCPP organic ligands, thereby inducing ferroptosis and augmenting cancer cell death. Immunogenic cell death (ICD) triggers a sustained anti-cancer immune response, amplifying the effectiveness of conventional anticancer treatments. Furthermore, the nanocomplex, coated with an anti-PD-L1 antibody, presents a multifaceted strategy with significant potential for cancer immunotherapy. Additionally, mild hyperthermia induced by the iron oxide photothermal effect enhances immune responses, synergizing effectively with ICIs in "cold" tumors.