[1PS-099]
우수논문발표상 응모자Versatile π–π Interactive Hydrogel System for Conformable and Sustained Delivery of Aromatic Ring–Containing Therapeutics
발표자이예성 (성균관대학교 (자연과학캠퍼스))
연구책임자신미경 (성균관대학교)
Abstract
Sustained and localized delivery of aromatic drugs remains a challenge in biomaterial design. We developed a hydrogel (CHI-TA) via Schiff-base crosslinking between chitosan and terephthalaldehyde (TA). Aromatic rings of TA enable π–π stacking with conjugated drugs, supporting extended release without added processing. In a curcumin-loaded model, the hydrogel reduced burst release and retained drug locally. It forms within 20 s at body temperature and adheres to wet tissue, with adhesion >5.5 kPa, stiffness >40 kPa, and stability over 30 compressions. The gel remains intact in physiological conditions and shows better cytocompatibility and tissue integration than glutaraldehyde-based gels. In rat bleeding models, CHI-TA achieved hemostasis in under one minute and reduced blood loss by over 65%. These findings highlight its potential for delivering π-conjugated drugs in biomedical settings requiring tissue adherence and mechanical resilience.