[3PS-039]
Lipid–PLGA Hybrid Nanoparticles for Enhanced Drug Delivery in Solid Tumors
발표자김누리한 (Delft University of Technology)
연구책임자한정연 (가천대학교)
Abstract
Drug delivery to solid tumors is challenged by hypoxia, acidic pH, and high interstitial pressure, which hinder drug penetration and therapeutic efficacy. This study investigates lipid–PLGA hybrid nanoparticles as a strategy to overcome these barriers. PLGA offers biocompatibility and controlled drug release, while the lipid layer enhances membrane interaction and cellular uptake, improving drug stability and intracellular retention.
Synthesized lipid–PLGA nanoparticles will be characterized for their physicochemical properties. To evaluate functional performance, a fluorescent model drug will be encapsulated to quantify drug loading efficiency and cellular uptake, comparing coated and uncoated PLGA nanoparticles. In addition, Gemcitabine, a chemotherapeutic agent, will be employed to assess therapeutic efficacy under tumor-mimicking conditions. This platform holds potential for future integration with diverse functional modules to address key delivery challenges in solid tumors.