[3PS-079]
Upconversion Nanoplatform co-doped with Gd and Fe for multimodal theranostic applications
발표자AJITH KUMAR LAKSHMANAN (Chungnam National University)
연구책임자김소연 (충남대학교)
Abstract
Multimodal cancer theranostics, integrating therapy and diagnosis in a single system, has attracted significant attention. Photodynamic (PDT) and photothermal therapy (PTT) are non-invasive treatments where a photosensitizer, upon light excitation, induces cancer cell death via reactive oxygen species or localized hyperthermia, respectively. Magnetic resonance imaging (MRI) provides accurate tumor visualization using contrast agents. However, conventional organic agents often suffer from poor stability and long-term toxicity. To address this, we propose an upconversion nanoparticle (UCNP) system with optimized gadolinium (Gd) and iron (Fe) content in the core and shell to enhance PDT and PTT effects. The Gd and Fe also enable dual-mode T₁/T₂ MRI imaging. This multifunctional UCNP platform presents a promising strategy for integrated cancer diagnosis and treatment.