[3PS-057]
Synthesis of Fluorinated and Iodinated Cyanoacrylates and Their Application to Novel Liquid Embolic Composition
발표자박현재 (서울대학교)
연구책임자안철희 (서울대학교)
Abstract
Liquid embolic agents are increasingly used in endovascular procedures due to their permanence, injectability, and high filling efficiency. However, Histoacryl® has limitations such as poor radiopacity and strong microcatheter adhesion. To overcome this, a new embolic composition combining iodinated (IECA) and fluorinated (PFPCA) cyanoacrylates was developed. IECA offers high radiopacity (1,100 mgI/mL), while PFPCA provides fast polymerization (15.77 ± 1.96 μL/s) and low catheter adhesion (8.65 ± 0.79 N), improving usability. In rabbit renal artery embolization, the mixture with ethyl oleate achieved complete vessel occlusion and durable embolic effect, demonstrating its clinical potential.